Are you interested in clinical metagenomics? We are hosting a webinar on this topic on December 8, 3:30 p.m. CET, and you’re welcome to join. You can sign up here.
Title: Clinical Metagenomics for Rapid Detection of Enteric Pathogens and Characterization of the Intestinal Microbiome in Health and Disease
Speaker: Dr. Rita R. Colwell, Distinguished University Professor, University of Maryland, College Park, and Johns Hopkins University Bloomberg School of Public Health
High-throughput sequencing, combined with high-resolution metagenomic analysis, provides a powerful diagnostic tool for clinical management of enteric disease. Forty-five patient samples of known and unknown disease etiology and 20 samples from health individuals were subjected to next-generation sequencing. Subsequent metagenomic analysis identified all microorganisms (bacteria, viruses, fungi and parasites) in the samples, including the expected pathogens in the samples of known etiology. Multiple pathogens were detected in the individual samples, providing evidence for polymicrobial infection.
Patients were clearly differentiated from healthy individuals based on microorganism abundance and diversity. The speed, accuracy and actionable features of CosmosID bioinformatics and curated GenBook® databases, implemented in the QIAGEN Microbial Genomics Pro Suite, and the functional analysis, leveraging the QIAGEN functional metagenomics workflow, provide a powerful tool contributing to the revolution in clinical diagnostics, prophylactics and therapeutics that is now in progress globally.