Latest improvements for Ingenuity Pathway Analysis

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Ingenuity Pathway Analysis 1.1

Release date: 2016-12-01

What's new in the IPA Summer 2019 Release

New overlay feature, additional filters and two new canonical pathways

 

Explore new Canonical Pathways related to two important research topics

Enhance your research and discovery of the mechanisms driving the development of lupus and cancer immunotherapy with these new pathway maps:

Quickly add contextual data to any network or pathway with Search and Overlay

Now from the Overlay tool, you can search for analyses and datasets to overlay onto networks and pathways, rather than by manually browsing in the Project Manager tree. Furthermore, Analysis Match analyses and datasets from OmicSoft are included in the search results for users with an Analysis Match IPA license.

This workflow enables rapid visual assessment of any analysis or dataset on the pathway or network of interest. The figure below shows the Interferon Signaling Pathway overlain with expression data from mouse lung infected with an Influenza A virus vs. uninfected lung (analysis from GEO dataset GSE36328 as processed by OmicSoft for Analysis Match).

 

Focus on what’s important to you in your Core Analysis with additional filters

In this release, many more columns in the Core Analysis tabs are filterable, which will help you narrow down and focus your results. Furthermore, now you can use the less than (<) or greater than (>) symbols to tailor the results.

The new filters can be found in the following tabs: Upstream Analysis, Diseases & Functions, Regulator Effects, Networks, and Molecules. Some of the filters also appear in Comparison Analyses.

 

Clearer descriptions of Analysis Match datasets and analyses

Metadata values that differ between case and control are now displayed in a table at the top of the metadata panel in the Project Search results. An example is shown in the figure below.

Also, specific fields that are important in understanding the dataset (such as the organism, tissue and platform) have been extracted into a small section called “Comparison Context” that follows the case/control table.

If you have chosen to use the standard IPA case and control metadata keys for your datasets, they will also be automatically displayed in a table and placed into the Comparison Context section.

 


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