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NGS Features

All the tools you need, integrated into a single user friendly and scalable application, and ready to generate results you can trust. Powered by cutting-edge technology and accelerated algorithms CLC Genomics Workbench supports a comprehensive set of NGS data analysis applications.




CLC Genomics Workbench supports the complete resequencing pipeline for detecting and comparing genetic variants. When dealing with high sample volumes efficient algorithms reduce run time while customizable analysis workflows and batch processing shorten hands-on time to a minimum.
CLC Genomics Workbench allows you to focus on the biological interpretation of detected variants.


Read mapping

The first step in resequencing is accurate read mapping. Our algorithm is optimized for high-quality mapping of large data volumes in a fast and memory-efficient way.
The algorithm offers comprehensive support for a variety of data formats, including both short and long reads, and all flavors of paired read data regardless of insert size or read orientation. It also supports the use of hybrid data sets. Local realignment can drastically reduce false positive detection rates for certain variant types. Our goal is to reduce your manual work and focus on deriving biological meaningful results from raw NGS reads.


Transcription factor ChIP-Seq

Recent improvements promise deeper insights into transcriptional regulation even in the absence of control sample. Transcription factor ChIP-seq exposes defined peak regions characteristic of transcription binding sites throughout the whole genome. All made accessible through our tried and trusted interactive graphical user interface.


Bisulfite Sequencing

Cytosine methylation is probably the best-studied form of epigenetic regulation of gene expression. The Bisulfite Sequencing plugin for CLC Genomics Workbench offers an all-in-one solution to common problems that scientists face when studying cytosine methylation data.



Workflows streamline selected tools into one analysis. Workflows can be run in batch making them a powerful tool for processing large numbers of samples with minimal user interventions. You can easily set up your own workflows and create and share workflow installer files with colleagues or other researchers following your scientific publications. Commercial add-ons introduce preconfigured example workflows to get you from data to publication faster.


De novo assembly

Our trusted de novo assembler accompanied by trimming tools to remove low quality data deliver assembly quality fast and compute resource efficient. Like for our read mapper, a wide range of NGS data types is supported, and hybrid assemblies combine the unique strength of short and long reads for optimal results. If assembly of long reads (like PacBio) or genome finishing are the primary focus, then CLC Genomics Workbench can be enhanced with the commercial CLC Genome Finishing Module.



The free “Advanced RNA-Seq plugin” integrates all the analysis steps – from secondary analysis of the reads to sophisticated statistics – into easy-to-use workflows, and gives access to a wide range of experimental designs, from case-control or multi-group experiments to multi-factorial experiments. All tools account for differences due to sequencing depth, removing the need to normalize input data. Multi-factorial statistics control for batch effects and support paired studies. Statistical results can be visualized in a genomic context as tracks, in a table view, or through the many visualization options leveraging metadata: volcano plots, 2D Heatmaps, Principal Component Analysis and Venn diagrams.



Histone ChIP-Seq plugin

Acetylation of histones is an important epigenetic adaptation associated with chromatin decondensation and up-, or down-regulated gene expression. The Histone ChIP-Seq plugin for CLC Genomics Workbench detects evidence for Histone acetylation marks in genes or other predefined genomic regions.


Variant Analysis

CLC Genomics Workbench offers a range of accurate variant detectors to detect single nucleotide variants (SNVs), multi-nucleotide variants (MNVs), small to medium sized insertions, deletions or replacements, as well as large structural variants. Algorithms for the sensitive detection of so called “low frequency” variants supported only by a small fraction of mapped reads complete the detection tools.To make sense of detected variants CLC Genomics Workbench offers a range of filter and comparison tools.


Uncover critical correlations between microbiota, its metagenome, and host. Making sense of complex metagenomic data becomes easy through tools and streamlined analysis workflows for taxonomic and functional microbiome analysis. With commercial add-ons like CLC Microbial Genomics Module (hyperlink) the workbench turns into a leading solution for microbiologists.

And there is more:
With CLC Genomics Workbench you can enjoy more tools that belong into every bioinformatician’s repertoire. Enjoy a rich set of phylogenetic tools, create your own BLAST Searches, design PCR or real-time PCR primers, and take advantage of 10 years of molecular biology tool development.