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Tuesday, November 26, 2019

QIAGEN Digital Insights Publication Roundup

Researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications

Powerful insights help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA),  QIAGEN CLC and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in the NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference. 

Selected publications:


QIAGEN IPA

Proteomic profiling of extracellular vesicles isolated from cerebrospinal fluid of former national football league players at risk for chronic traumatic encephalopathy

First author: Satoshi Muraoka

Dr. S. Muraoka and colleagues look at the proteomic profile of cerebrospinal fluid samples from former NFL players to understand the biology of chronic traumatic encephalopathy, a condition that affects individuals with a history of repetitive mild traumatic brain injury. In this research paper, the team use QIAGEN Ingenuity Pathway Analysis to look at upstream regulators, pathways and functional networks of the differentially expressed proteins to identify a plausible biomarker.

Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

First author: Lei Tan

Crucial research by Dr. L. Tan and colleagues from Weill Cornell Medical College strives to reveal the outcomes of a Zika virus infection during the pre- and peri-implantation stage of pregnancy. Learn how the team used QIAGEN Ingenuity Pathway Analysis to identify two key gene networks that are strongly affected by the virus.

Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior

First author: Zuzanna Misiewicz

Check out this interesting paper by Dr. Z. Misiewicz and colleagues from University of Helsinki who use a multi-‘omics approach to understand the molecular mechanisms behind anxiety and stress disorders. Discover how the team use QIAGEN Ingenuity Pathway to identify certain mitochondrial genes in blood cells related to these debilitating disorders.


Microbe-host interplay in atopic dermatitis and psoriasis

First author: Nanna Fyhrquist

Interesting research by Dr. N. Fyhrquist and colleagues from the Karolinska Institute who study the interplay between the skin microbiome and skin diseases such as dermatitis and psoriasis. The team use QIAGEN Ingenuity Pathway Analysis to identify key regulators and pathway activation in host cells to identify transcriptomic signatures for skin barrier function, tryptophan metabolism and immune activation as a basis for plausible biomarkers and targeted therapies.

Zinc chelation specifically inhibits early stages of Dengue virus replication by activation of NF-κB and induction of antiviral response in epithelial cells

First author: Meenakashi Kar

Dr. M. Kar and colleagues from Translational Health Science and Technology Institute in Faridabad, India (THSTI)  perform cutting-edge immunology research using QIAGEN Ingenuity Pathway Analysis to understand how zinc chelation can inhibit early stages of Dengue virus by activating NFkB to induce an antiviral response in epithelial cells.

QIAGEN CLC

Genome sequence of a novel Enterococcus faecalis sequence type 922 strain isolated from a door handle in the intensive care unit of a district hospital in Durban, South Africa

First author: Christiana Shobo

December 1–7 is National Handwashing Awareness Week. Washing your hands is one of the easiest ways to prevent overuse of antibiotics and fight antimicrobial resistance. This work by Dr. C. Shobo and colleagues from the University of KwaZulu-Natal demonstrate this by using QIAGEN CLC Genomics Workbench to investigate the resistome of a novel Enterococcus faecalis found on the door handle of an intensive care unit (ICU) in South Africa. Check it out!

Human perivascular stem cell-derived extracellular vesicles mediate bone repair

First author: Jiajia Xu

Interesting research by Dr. J Xu and colleagues from Johns Hopkins University show how extracellular vesicles (EVs) derived from human perivascular stem cells (PSCs) are able to repair bone by stimulating osteoblasts just like PSCs. Discover how the team use QIAGEN CLC Genomics Server and Workbench to understand the transcriptomics of the EVs.

Comparative modulation of lncRNAs in wild-type and rag1-heterozygous mutant zebrafish exposed to immune challenge with spring viraemia of carp virus (SVCV)

First author: Valentina Valenzuela-Muñoz

Research by V. Valenzuela-Muñoz and colleagues from University of Concepción use QIAGEN CLC Genomics Workbench to discover the role of long non-coding RNAs (lncRNAs) in the infection of zebrafish with spring viraemia of carp virus.

Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells

First author: Maria Harmati

M. Harmati and colleagues from the University of Szeged use both QIAGEN CLC Genomics Workbench and QIAGEN Ingenuity Pathway Analysis to investigate how extracellular vesicles from melanoma cells convey adaptive stress responses. In their paper, they leverage these insights to illustrate how to predict different stress responses which could influence efficacy of treatments based on therapy-induced host responses.

QIAGEN OmicSoft Array Suite and Lands

Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model

First author: Haiyan Xu

Dr. H. Xu and colleagues from Merck study the ability of bone marrow cells from acute myeloid leukaemia (AML) patients to resist cancer treatment in a 3D cell culture system. Read how the team use QIAGEN OmicSoft Studio to identify unique gene expression signatures and novel genetic mutations associated with sensitivity to Ara‐C treatment in proliferating AML cells. These unique signatures could potentially be used as predictive biomarkers to determine optimal treatment regimens.

Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo

First author: Kathleen M. McAvoy

Interesting research from Dr. K. McAvoy and colleagues from Biogen and Harvard Medical School who study the genetic contribution of neuronal-specific BIN1 isoforms in late onset Alzheimer’s disease. Learn how the team use QIAGEN OmicSoft Array Studio and QIAGEN Ingenuity Pathway Analysis to look at gene enrichment and activated pathways in BIN1-knockout mice to better understand this disease.

To request information on the QIAGEN Digital Insight Solutions, contact [email protected].